Cure MSA

Country specific patient information

University College London - Queen Square


Principal investigator:
Prof. Clare Fowler

University College London
Institute of Neurology
Queen Square
WC1N 3 BG London UK


Expertise of the participating organisation:

The Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Queen Square, is the foremost specialist clinical and research centre in neurology in the United Kingdom. It has a unique concentration of academic consultants with a clinical and research interest in MSA. Professor Quinn is a retired Neurologist who has published widely on MSA, particularly in collaboration with Professor Wenning in Innsbruck), and also with Professor Tison in Bordeaux and with Professor Brooks in London . He developed the most widely used clinical diagnostic criteria for MSA. Professor Mathias, Professor of Neurovascular Medicine, directs the Autonomic Unit (Queen Square) and Neurovascular Medicine Unit (St Mary's Hospital) these are national centres, with many European referrals, for various autonomic disorders, especially MSA. The Units have pioneered new methods of diagnosis and been principal investigators in therapeutic trials in MSA.
Professor Fowler, Professor in Uro-neurology, is the first and only uro-neurologist in the UK, and the leading authority on uro-neurological and genital dysfunction in parkinsonism and MSA. All of the above have a special clinical and research interest in MSA, they all have a substantial MSA patient base, and have all published extensively, often together, on MSA.


Recent publications relevant to the EMSA-SG:

 

Quinn N, Barker RA, Wenning GK. Are trials of intravascular infusions of autologous mesenchymal stem cells in patients with multiple system atrophy currently justified, and are they effective? Clin Pharmacol Ther 2008; 83: 663-5. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18425088

 

Schrag A, Wenning GK, Quinn N, Ben-Shlomo Y. Survival in multiple system atrophy. Mov Disord 2008; 23: 294-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18044727

 

Schrag A, Selai C, Mathias C, Low P, Hobart J, Brady N, et al. Measuring health-related quality of life in MSA: the MSA-QoL. Mov Disord 2007; 22: 2332-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17914730

 

Mathias CJ. Multiple system atrophy and autonomic failure. J Neural Transm Suppl 2006: 343-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17017551

 

Paviour DC, Williams D, Fowler CJ, Quinn NP, Lees AJ. Is sphincter electromyography a helpful investigation in the diagnosis of multiple system atrophy? A retrospective study with pathological diagnosis. Mov Disord 2005; 20: 1425-30. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16007638

 

Quinn NP. How to diagnose multiple system atrophy. Mov Disord 2005; 20 Suppl 12: S5-S10. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16092074

 

The Imperial College of Sciences Technology and Medicine - MRC Cyclotron Unit

 

Principal investigator:
Prof. David J. Brooks

The Imperial College of Sciences
Technology and Medicine
MRC Cyclotron Unit
150 DuCane Road
W12 0NN London UK
david.brooks(at)csc.mrc.ac.uk

Expertise of the participating organization:

Professor Brooks and his team at the MRC Cyclotron Unit have been performing PET studies in-patients with typical and atypical parkinsonian syndromes since 1986. They have a variety of metabolic and ligand tracers available including markers of dopaminergic, opioid, GABA, adenosine, substance P, and microglial function.


Recent publications relevant to the EMSA-SG:

 

Berding G, Brucke T, Odin P, Brooks DJ, Kolbe H, Gielow P, et al. [[123I]beta-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson's disease and multiple system atrophy. Nuklearmedizin 2003; 42: 31-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12601452

 

Gerhard A, Banati RB, Goerres GB, Cagnin A, Myers R, Gunn RN, et al. [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy. Neurology 2003; 61: 686-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12963764

 

Hu MT, Chaudhuri KR, Jarosz J, Yaguez L, Brooks DJ. An imaging study of parkinsonism among African-Caribbean and Indian London communities. Mov Disord 2002; 17: 1321-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12465076

 

Chaudhuri KR, Hu MT, Brooks DJ. Atypical parkinsonism in Afro-Caribbean and Indian origin immigrants to the UK. Mov Disord 2000; 15: 18-23. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10634237

 

Reuter I, Hu MT, Andrews TC, Brooks DJ, Clough C, Chaudhuri KR. Late onset levodopa responsive Huntington's disease with minimal chorea masquerading as Parkinson plus syndrome. J Neurol Neurosurg Psychiatry 2000; 68: 238-41. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10644798

 

University of College London - PDS Brain Research Centre



Principal investigator:
 
Prof. Andrew Lees

University of College London
PDS Brain Research Centre
Institute of Neurology
1 Wakefield Street
WC1N 1 PJ London UK
a.lees(at)ion.ucl.ac.uk

Expertise of the participating organization:


The PDS-BRC (Parkinson's Disease Society Brain Bank Research Centre) is the largest dedicated brain tissue resource for Parkinson syndromes in the world with a collection of more than 800 Parkinsonian brains. Over the last ten years it has been responsible for " feeding research" in house and in other laboratories nationally and internationally leading to improved understanding of the pathogenesis of parkinson syndromes including MSA.


Recent publications relevant to the EMSA-SG:

 

 

O'Sullivan SS, Holton JL, Massey LA, Williams DR, Revesz T, Lees AJ. Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy. J Neurol Neurosurg Psychiatry 2008; 79: 232-4. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17951280

 

O'Sullivan SS, Massey LA, Williams DR, Silveira-Moriyama L, Kempster PA, Holton JL, et al. Clinical outcomes of progressive supranuclear palsy and multiple system atrophy. Brain 2008; 131: 1362-72. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18385183

 

Williams DR, Lees AJ. How do patients with parkinsonism present? A clinicopathological study. Intern Med J 2008. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18422568

 

Williams DR, Warren JD, Lees AJ. Using the presence of visual hallucinations to differentiate Parkinson's disease from atypical Parkinsonism. J Neurol Neurosurg Psychiatry 2007. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17872984

 

Williams DR, Watt HC, Lees AJ. Predictors of falls and fractures in bradykinetic rigid syndromes: a retrospective study. J Neurol Neurosurg Psychiatry 2006; 77: 468-73. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16543524

 

Pirtosek Z, Jahanshahi M, Barrett G, Lees AJ. Attention and cognition in bradykinetic-rigid syndromes: an event-related potential study. Ann Neurol 2001; 50: 567-73. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11706961