Cure MSA

Country specific patient information


Principal investigator:

Dr. Ruth Djaldetti

Department of Neurology,
Rabin Medical Center,
Beilinson Campus,
49100 Petach-Tiqva,

Expertise of the participating organization:

The Movement Disorder Clinic of Rabin Medical Center, Petah Tiqva, Israel, is a tertiary-care facility that treats mainly patients with parkinsonian disorders. The head of the clinic is Dr. Ruth Djaldetti, a senior staff member in the Department of Neurology. Dr. Djaldetti has conducted many clinical and research studies in patients with Parkinson?s disease and MSA. She also gained important experience in basic research on animal models of Parkinson?s disease as a research fellow at Columbia University in New York. The Department of Neurology is headed by Professor Eldad Melamed, a movement disorder specialist. Professor Melamed is also the director of the National Parkinson Foundation (U.S.A), Center of Research Excellence, and of the Laboratory of Neuroscience, Felsenstein Research Center.
The main interest of the laboratory is exploration of the mechanisms responsible for neurodegenerative diseases. Much effort is currently being invested in stem cell transplantation into the striatum in animal models of Parkinson?s disease and plans are underway to expand this approach to models of MSA.

Recent publications relevant to the EMSA-SG:

Yust-Katz S, Tesler D, Treves TA, Melamed E, Djaldetti R. Handedness as a predictor of side of onset of Parkinson's disease. Parkinsonism Relat Disord 2008.


Djaldetti R, Treves TA, Ziv I, Melamed E, Lorberboym M. 123I-FP-CIT SPECT imaging of dopamine transporters in patients with recurrent sudden falls: are such falls a distinct entity? J Nucl Med Technol 2007; 35: 232-6.


Djaldetti R, Yust-Katz S, Kolianov V, Melamed E, Dabby R. The effect of duloxetine on primary pain symptoms in Parkinson disease. Clin Neuropharmacol 2007; 30: 201-5.


Melamed E, Ziv I, Djaldetti R. Management of motor complications in advanced Parkinson's disease. Mov Disord 2007; 22 Suppl 17: S379-84.


Dabby R, Djaldetti R, Shahmurov M, Treves TA, Gabai B, Melamed E, et al. Skin biopsy for assessment of autonomic denervation in Parkinson's disease. J Neural Transm 2006; 113: 1169-76.


Djaldetti R, Ziv I, Melamed E. The mystery of motor asymmetry in Parkinson's disease. Lancet Neurol 2006; 5: 796-802.


Djaldetti R, Hellmann M, Melamed E. Bent knees and tiptoeing: late manifestations of end-stage Parkinson's disease. Mov Disord 2004; 19: 1325-8.


Djaldetti R, Giladi N, Hassin-Baer S, Shabtai H, Melamed E. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson's disease: an open-label, randomized, crossover study. Clin Neuropharmacol 2003; 26: 322-6.